A Semantic Web View of Kinases and their relation to Diseases

Kinases are a major target for many drugs, including many anti-cancer therapies. They play a set of very important roles in molecular biology, and many diseases are affected by them in some way. The various categories of Kinases and their relation to diseases have been compiled by researchers. The molecular basis of their role in diseases is known for quite a few of them, and continues to grow-- this knowledge is sometimes referred to as the Kinome.

The following information on Kinases was obtained from Fabian et al. and Cell Signaling (http://www.cellsignal.com/reference/kinase_disease.html), and the tables were converted directly into RDF (source), the Semantic Web format, using Babel. The RDF is rendered as an interactive web page using Exhibit. The various row colors represent different Kinase Groups or Families.

Feel free to send me any questions or suggestions you may have on this data viewer.

How to use the Exhibit View: Click on the table headers to sort a column in descending or ascending order. The various links in the cells are either semantic node links (in which case if the kinase gene is identified with a mutant gene from CGP, you will see ALL the semantically combined info!), or links to other resources such as OMIM. Links to clone sequences are also accessible. The three facet views on the right represent the different types for the Kinase Groups, Diseases, and Molecular Basis Categories. By selecting any combination of their listed types, the view will display only those filtered entries. The numbers left of each type indicate how many visible entries match each type. Alternative pivot-plots can be viewed by clicking on the above menus; for example, you can click on COMPOUND X DISEASE see what diseases can be treated by compounds, as well as those that are not yet treatable. Current views are underlined in red and preserve the facets already selected. You can shift to an Drug Interaction View by clicking on the link below. A snap-shot of any current data view can be "copied" as RDF by clicking on the scissor icon.

Go To Drug Interactions View Go To Cancer Genome View
Interaction: :: *BindingDB*

Kd (μM)=       IC50 (μM)=

Published Assay type: ""
Reference:
Clone: (NCBI)

Clone_Type:

Gene Symbol: